Study of ABCB1 polymorphism (C3435T) in HIV-1-infected individuals from South India
نویسندگان
چکیده
منابع مشابه
Subtype & cytokine profiles of HIV infected individuals from south India.
BACKGROUND & OBJECTIVE The global surveillance of human immunodeficiency virus (HIV) subtypes (clades) helps understand the global distribution and incidence of different HIV subtypes. As knowledge about subtypes circulating in an area is needed for developing a candidate vaccine, prevalence of the subtypes HIV-1 and HIV-2 were studied in south India. The profile of cytokines interleukin 10 (IL...
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متن کاملPrevalence of MDR1 C3435T and CYP2B6 G516T Polymorphisms among HIV-1 Infected South African Patients
Data on genetic polymorphisms associated with response to anti-HIV drugs has accumulated over the years. Information on how polymorphisms influence drug metabolism and transport to target sites is important in guiding dosage or selection of appropriate alternative therapies. This study determined the frequency of MDR1 C3435T and CYP2B6 G516T polymorphisms associated with the transport and metab...
متن کاملExpression of cytokine-mRNA in PBMC of HIV-1 subtype C infected individuals with opportunistic viral infections from South India
Results The mRNA expressions of all the 4 cytokines in HIV-1 infected individuals were significantly higher compared to healthy controls (p value range 0.0004-0.01). The mean level of IL-10, INF-gamma and TNF alpha were higher in HIV infected individuals with low CD4 counts (<300 cells/μL). The IL-10 expression showed a significant negative correlation with CD4 counts (r = -0.25, p = 0.04) whil...
متن کاملChemokine profile among human immunodeficiency virus-1 (HIV-1) infected individuals from southern India.
BACKGROUND & OBJECTIVE Individuals infected with HIV-1 have higher levels of chemokine producing cells compared to uninfected individuals. It is important to know the changes in chemokine levels associated with rate of progression of disease. There is a paucity of information on the plasma chemokines in HIV-1 infected individuals from India. We therefore carried out this study to estimate the l...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 2008
ISSN: 0306-5251,1365-2125
DOI: 10.1111/j.1365-2125.2007.03093.x